BDBM237183 Ranitidine
Zantac Ranitidine Tritec BDBM50103506
ZANTAC dimethyl[(5-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine Ranitidine BDBM22893 CHEMBL512
- Sowell, JW; Tang, Y; Valli, MJ; Chapman, JM; Usher, LA; Vaughan, CM; Kosh, JW Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine. J Med Chem 35: 1102-8 (1992)
- Gao, J; Midde, N; Zhu, J; Terry, AV; McInnes, C; Chapman, JM Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease. Bioorg Med Chem Lett 26: 5573-5579 (2016)
- Valli, MJ; Tang, Y; Kosh, JW; Chapman, JM; Sowell, JW Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine. J Med Chem 35: 3141-7 (1992)
- Esterase Activity Assay CA activity was assayed according to method of Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] described previously by Innocenti et al. [Innocenti et al., Bioorg. Med. Chem., 18:2159-2164; Innocenti et al., Bioorg. Med. Chem. Lett., 20:5050-5053] CA activity was determined by following thechange in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a period of 3 min at 25°C using a spectrophotometer (CHEBIOS UV-VIS). The enzymatic reaction, in a total volume of 3.0 mL, contained 1.4 mL 0.05 M Tris-SO4 buffer (pH 7.4), 1 mL, 3 mM 4-nitrophenylacetate, 0.5 mL H2O and 0.1 mL enzyme solution. A reference measurement was obtained by preparing the same cuvette without enzyme solution. The inhibitory effects of ampicillin sulfate, ceftriaxone, ceftizoxime, ranitidine were examined. All compounds were tested in triplicate at each concentration used. Different inhibitor concentrations were used. HCA-I enzyme activities were measured for ceftriaxone (0.003-0.033 mM), ceftizoxime (0.017-0.096 mM), ranitidine (0.026-0.053 mM) at cuvette concentrations and HCAII enzyme activities were measured for ampicillin sulfate (0.038-0.095 mM), ceftriaxone (0.003-0.021 mM), ceftizoxime (0.026-0.061 mM) and ranitidine (0.032-0.058 mM) at cuvette concentrations.